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If it proves ineffective and another type of infertility treatment will be recommended. Clomid sends a message to the pituitary gland to release the hormones which control the ovary. There research findings were reported stating that Clomid increased a woman's ovaries to mature an increased number of follicles every month. A series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. Clomid therapy should not be initiated until a semen analysis has been completed. Clomid has been used to induce ovulation.